393-11-3
- Product Name：4-Nitro-3-trifluoromethyl aniline
- Molecular Formula：C7H5F
- Purity：99%
- Molecular Weight：206.124
Product Details;
CasNo： 393-11-3
Molecular Formula： C7H5F
Appearance： light yellow crystal powder
Factory sells 4-Nitro-3-trifluoromethyl aniline 393-11-3 with sufficient production capacity
- Molecular Formula:C7H5F
- Molecular Weight:206.124
- Appearance/Colour:light yellow crystal powder
- Vapor Pressure:2.78E-06mmHg at 25°C
- Melting Point:125-129 °C(lit.)
- Refractive Index:1.532
- Boiling Point:326.4 °C at 760 mmHg
- PKA:-0.22±0.10(Predicted)
- Flash Point:151.2 °C
- PSA：71.84000
- Density:1.503 g/cm3
- LogP:3.30020
4-Nitro-3-trifluoromethyl aniline(Cas 393-11-3) Usage
|
Synthesis |
The thiazolium salt 3 (3.30 mg, 0.0122 mmol) was added to a solution of 1-azido-4-nitrobenzene (0.122 mmol) and t-BuOH (18.0 mg, 0.244 mmol) in degassed THF (0.50 mL) under argon at r.t. The resulting suspension was stirred for 5 min, and then NaOt-Bu (23.4 mg, 0.244 mmol) was added in one portion, and the mixture was stirred (Table 2). Water (2 mL) was added, and the products were extracted with EtOAc (2 × 2 mL), the combined organic phase was dried over anhyd MgSO4, filtered, and concentrated in vacuo. Purification was achieved by passing the resulting residue through a short pad of silica (eluting with 50% light PE-EtOAc) unless otherwise stated. 4-Nitro-3-trifluoromethyl aniline, Time: 12 h, Pale yellow solid (21.0 mg, 84%). (70:30 petrol-EtOAc) 0.5; mp 90-93 °C (lit., 92-93 °C); IR (FTIR, CHCl3) νmax cm-1: 3535 (NH2), 3434 (NH2), 1635, 1592 (NO2), 1520 (NO2), 1119; 1H NMR (400 MHz, DMSO-6) 8.59 (d, = 2.7 Hz, 1H), 8.55 (dd, = 9.3, 2.7 Hz, 1H), 7.55 (br s, 2H), 7.32 (d, = 9.3 Hz, 1H); 13C NMR (100 MHz, DMSO-6) 151.8 (C), 135.0 (C), 128.7 (CH), 123.7 (J = 5.9 Hz, F3N2NaO2 [M+Na]+, 229.0195; found, 229.0195.Fig. The synthetic of 4-Nitro-3-trifluoromethyl aniline |
InChI:InChI=1/C9H7F3N2O3/c1-5(15)13-6-2-3-8(14(16)17)7(4-6)9(10,11)12/h2-4H,1H3,(H,13,15)
393-11-3 Relevant articles
The influence of pH and temperature on the stability of flutamide. An HPLC investigation and identification of the degradation product by EI+-MS
El-Shaheny,Yamada
, p. 3206 - 3214 (2015)
The chemical stability of flutamide (FLT...
The photochemistry of flutamide and its inclusion complex with β-cyclodextrin. Dramatic effect of the microenvironment on the nature and on the efficiency of the photodegradation pathways
Sortino,Giuffrida,De Guidi,Chillemi,Petralia,Marconi,Condorelli,Sciuto
, p. 6 - 13 (2001)
The photochemistry of the anticancer dru...
Two different spectrophotometric determinations of potential anticancer drug and its toxic metabolite
Farid, Nehal F.,Abdelwahab, Nada S.
, p. 360 - 367 (2015)
Flutamide is a hormone therapy used for ...
Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control
Garg, Neeraj,Hansson, Annelie,Knych, Heather K.,Stanley, Scott D.,Thevis, Mario,Bondesson, Ulf,Hedeland, Mikael,Globisch, Daniel
supporting information, p. 698 - 702 (2018/02/09)
Selective androgen receptor modulators (...
Catalytic reduction of ortho - And para -azidonitrobenzenes via tert -butoxide ion mediated electron transfer
Burnley, James,Carbone, Giorgio,Moses, John E.
supporting information, p. 652 - 656 (2013/04/10)
The reduction of a range of substituted ...
393-11-3 Process route
-
-
384-22-5
2-nitrobenzotrifluoride
-
-
393-11-3
4-nitro-3-(trifluoromethyl)benzeneamine
| Conditions | Yield |
|---|---|
|
With
potassium tert-butylate; N,N-tetramethylene-thiocarbamoyl-sulphenamide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.333333h;
|
71% |
|
With
potassium tert-butylate; N,N-tetramethylene-thiocarbamoyl-sulphenamide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.333333h;
|
71% |
-
-
13311-84-7
Flutamide
-
-
393-11-3
4-nitro-3-(trifluoromethyl)benzeneamine
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
at 25 ℃;
|
|
|
With
sodium hydroxide;
In
ice-water; ethanol;
|
|
|
With
hydrogenchloride;
In
methanol; water;
at 100 ℃;
for 0.4h;
Reagent/catalyst;
Temperature;
pH-value;
Kinetics;
Activation energy;
|
|
|
With
sodium hydroxide;
In
methanol; water;
at 80 ℃;
for 3h;
Reagent/catalyst;
Temperature;
Concentration;
Kinetics;
Activation energy;
|
393-11-3 Upstream products
-
351-36-0
N-acetyl-3-trifluoromethylbenzenamine
-
393-12-4
4-nitro-3-trifluoromethylacetanilide
-
384-22-5
2-nitrobenzotrifluoride
-
13311-84-7
Flutamide
393-11-3 Downstream products
-
384-22-5
2-nitrobenzotrifluoride
-
118-83-2
5-chloro-2-nitrotrifluoromethylbenzene
-
88-30-2
3-trifluoromethyl-4-nitrophenol
-
393-10-2
4-iodo-1-nitro-2-(trifluoromethyl)benzene
Relevant Products
-
para-fluoro MethylaminorexCAS：1364933-64-1
-
Albuterol sulfateCAS：51022-70-9
-
1,3-Dimethylbutylamine HCLCAS：71776-70-0
