64461-82-1
- Product Name：Tizanidine hydrochloride
- Molecular Formula：C9H8ClN5S.HCl
- Purity：99%
- Molecular Weight：290.176
Product Details;
CasNo： 64461-82-1
Molecular Formula： C9H8ClN5S.HCl
Appearance： Off-white to pale yellow solid
Reliable Quality Tizanidine hydrochloride 64461-82-1 Hot Sale with Chinese Manufacturer
- Molecular Formula:C9H8ClN5S*ClH
- Molecular Weight:290.176
- Appearance/Colour:Off-white to pale yellow solid
- Vapor Pressure:2.51E-06mmHg at 25°C
- Melting Point:280 °C
- Boiling Point:391.2 °C at 760 mmHg
- Flash Point:190.4 °C
- PSA：90.44000
- LogP:2.35520
Tizanidine hydrochloride(Cas 64461-82-1) Usage
|
Biological Activity |
α 2 -adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC 50 = 48 nM). Also binds to imidazoline receptor. |
|
Brand name |
Tizanidine is INN and BAN. |
InChI:InChI=1/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H
64461-82-1 Relevant articles
Preparation method of tizanidine hydrochloride
-
Paragraph 0059-0068, (2021/07/21)
The invention discloses a preparation me...
Preparation method for benzothiadiazole derivative
-
Paragraph 0012; 0042; 0044-0045; 0047-0048; 0050-0051; 0053, (2019/04/10)
The invention discloses a preparation me...
Preparation method of imidazoline derivative
-
Paragraph 0120-0129; 0133; 0136, (2019/12/25)
The invention discloses a preparation me...
Preparation method of novel central skeletal muscle relaxant
-
Paragraph 0070-0072, (2018/03/24)
The invention discloses a preparation me...
64461-82-1 Process route
-
-
51322-75-9
tizanidine
-
-
64461-82-1,74113-36-3
tizanidine hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
ethanol;
at 20 ℃;
for 2h;
|
96.4% |
|
With
hydrogenchloride;
In
water;
at 20 ℃;
for 1h;
|
96.2% |
|
With
hydrogenchloride;
In
ethanol;
at 20 ℃;
for 2h;
Solvent;
Temperature;
|
83.5% |
|
tizanidine;
With
acetic acid;
In
acetone;
for 2h;
Reflux;
With
hydrogenchloride;
In
water; acetone;
for 2h;
Reagent/catalyst;
Solvent;
Reflux;
|
37.9 g |
|
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 5 - 10 ℃;
for 2h;
Solvent;
|
-
-
tizanidine glycolate
-
-
64461-82-1,74113-36-3
tizanidine hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
ethanol;
at 20 ℃;
for 6h;
|
97.5% |
64461-82-1 Upstream products
-
51322-75-9
tizanidine
-
30536-19-7
4-amino-5-chloro-2,1,3-benzothiadiazole
-
5391-39-9
1-acetylimidazolidin-2-one
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-
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