What is the Tamsulosin hydrochloride?

Tamsulosin hydrochloride is white to off-white solid, while it's Molecular Formula is C20H29ClN2O5S. white to off-white solid An α1-adrenoceptor antagonist

What is the CAS number for Tamsulosin hydrochloride?

The CAS number of Tamsulosin hydrochloride is 106463-17-6.

What is Tamsulosin hydrochloride (106463-17-6) used for?

Tamsulosin is a potent antagonist of α1-adrenergic receptors (α1-ARs; Ki = 0.229 nM in a radioligand binding assay). It is 3,800-fold selective for α1-ARs over α2-ARs (Ki = 871 nM). Tamsulosin antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA2 = 10.11) but has no effect on contraction stimulated by histamine, serotonin , angiotensin II , or prostaglandin F2α . In vivo, tamsulosin reverses the pressor effect of phenylephrine (Item Nos. 17205 | 18619) in pithed rats. It reversibly reduces fertility in male rats when administered at a dose of 0.15 mg/kg. Tamsulosin (1-100 μg/kg) also reduces prostatic pressure in a dose-dependent manner with minimal hypotensive effects in anesthetized dogs. Formulations containing tamsulosin have been used for the treatment of benign prostatic hyperplasia.InChI:InChI=1/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H

What is the Tamsulosin hydrochloride?

Tamsulosin hydrochloride is white to off-white solid, while it's Molecular Formula is C20H29ClN2O5S. white to off-white solid An α1-adrenoceptor antagonist

What is the CAS number for Tamsulosin hydrochloride?

The CAS number of Tamsulosin hydrochloride is 106463-17-6.

What is Tamsulosin hydrochloride (106463-17-6) used for?

Tamsulosin is a potent antagonist of α1-adrenergic receptors (α1-ARs; Ki = 0.229 nM in a radioligand binding assay). It is 3,800-fold selective for α1-ARs over α2-ARs (Ki = 871 nM). Tamsulosin antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA2 = 10.11) but has no effect on contraction stimulated by histamine, serotonin , angiotensin II , or prostaglandin F2α . In vivo, tamsulosin reverses the pressor effect of phenylephrine (Item Nos. 17205 | 18619) in pithed rats. It reversibly reduces fertility in male rats when administered at a dose of 0.15 mg/kg. Tamsulosin (1-100 μg/kg) also reduces prostatic pressure in a dose-dependent manner with minimal hypotensive effects in anesthetized dogs. Formulations containing tamsulosin have been used for the treatment of benign prostatic hyperplasia.InChI:InChI=1/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H

Product classification

106463-17-6

Product Name：Tamsulosin hydrochloride
Molecular Formula：C₂₀H₂₉ClN₂O₅S
Purity：99%
Molecular Weight：408.519

Inquiry

Product Details;

CasNo： 106463-17-6

Molecular Formula： C₂₀H₂₉ClN₂O₅S

Appearance： white to off-white solid

Quality Factory Supply 99% Pure Tamsulosin hydrochloride 106463-17-6 with Efficient Delivery

Molecular Formula:C20H29ClN2O5S
Molecular Weight:408.519
Appearance/Colour:white to off-white solid
Vapor Pressure:3.79E-14mmHg at 25°C
Melting Point:228-230 °C
Boiling Point:595.5 °C at 760 mmHg
Flash Point:313.9 °C
PSA：108.26000
LogP:4.51290

Tamsulosin hydrochloride(Cas 106463-17-6) Usage

Therapeutic Function	Antihypertensive
Hazard	Moderately toxic by ingestion.
Biological Activity	Selective α 1A -adrenoceptor antagonist (pK i values are 9.97, 9.64 and 8.86 for α 1A , α 1B and α 1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo .
Biochem/physiol Actions	Tamsulosin is an α1A/1D-adrenoceptor antagonist used as a treatment of benign prostatic hypertrophy (BPH). Its activity as an ? blocker also affects the iris, and has led to complications during cataract surgery, a condition called "floppy iris" syndrome.
General Description	Tamsulosin hydrochloride is a subtypeselective a1A and a1D adrenoceptor antagonist, which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component. It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.

InChI:InChI=1/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H

106463-17-6 Relevant articles

Continuous-Flow Synthesis of (R)-Tamsulosin Utilizing Sequential Heterogeneous Catalysis

Ishitani, Haruro,Kobayashi, Shū,Laroche, Benjamin,Nishizawa, Ken,Saito, Yuki

, (2022/02/16)

We describe the continuous-flow synthesi...

METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE

-

Page/Page column 12, (2010/04/25)

The present invention provides a method ...

Process for the resolution of racemic (R,S) -5-(2-(2-(2- ethoxyphenoxy) ethylamino)propyl)-2-methoxybenzene sulfonamide (tamsulosin), its novel R and S isomers and their salts and processes for their preparation

-

Page/Page column 8; 9, (2010/10/20)

An improved process is described to reso...

Process for the separation of R(-)-and S(+)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide

-

Page 6; Sheet 3, (2010/02/10)

The process for separating the R(?)- and...

106463-17-6 Process route

: 852619-17-1
C₂₀H₂₆N₂O₅S

: 106463-17-6,106138-88-9
(+)-Tamsulosin

: 106133-20-4,106138-88-9
(R)-tamsulosin

Conditions

Conditions	Yield
C₂₀H₂₆N₂O₅S; (S)-chloro[(1,2,3,4-η)-pentamethyl-2,4-cyclopentadien-1-yl] [N-(2-methoxy-3-dibenzofuranyl)-2-pyrrolidinecarboxamidato-κN1,κN2]iridium; In acetonitrile; at -3 - 3 ℃; for 0.5h; With formic acid; triethylamine; In acetonitrile; at -3 - 20 ℃;	41.4 % ee

: (R/S)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide D-10-camphorsulfonic acid salt

: 106463-17-6,106138-88-9
(+)-Tamsulosin

: 106133-20-4,106138-88-9
(R)-tamsulosin