941678-49-5

Cosmetics Grade Ruxolitinib 941678-49-5 For Sale with Good Price We supply high quality Ruxolitinib (CAS 941678-49-5), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the Ruxolitinib ?

Ruxolitinib is , while it's Molecular Formula is C17H18N6. INCB018424 is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3

What is the CAS number for Ruxolitinib ?

The CAS number of Ruxolitinib is 941678-49-5.

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What is Ruxolitinib (941678-49-5) used for?

In November 2011, the U.S. FDA approved ruxolitinib (INCB018424) for the treatment of patients with intermediate or high-risk myelofibrosis. Ruxolitinib is an ATP-competitive inhibitor of JAK1 and JAK2 (IC50's of 3.3±1.2 nM and 2.8±1.2 nM, respectively) and inhibition occurs regardless of the JAK2V617F mutational status. Ruxolitinib is a moderately potent inhibitor of the related JAK, TYK2 (IC50=19±3.2 nM) but is selective versus JAK3 (IC50=428±243 nM). It was also selective versus a panel of 26 other kinases at concentrations approximately 100-fold the IC50 of JAK1 and JAK2. Inhibition of JAK1 and JAK2 downregulates the JAK-signal transducer and activator of transcription (STAT) pathway, inhibiting myeloproliferation, inducing apoptosis, and reducing numerous cytokine plasma levels.

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