Product Details;
CasNo： 1191237-69-0
Quality products make an important contribution to long-term revenue and profitability. Hot sale! High purity GS-441524 1191237-69-0 powder in stock.
1.What is the GS-441524 ?
GS-441524, a novel nucleotide analog prodrug, has been proposed to be effective against Covid-19. GS-441524 showed excellent metabolic stability in human plasma and HLMs.
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![(2R,3R,4R,5R)‐2‐{4‐aminopyrrolo[2,1‐f][1,2,4]triazin‐7‐yl}‐3,4‐bis(benzyloxy)‐5‐[(benzyloxy)methyl]tetrahydrofuran‐2‐carbonitrile](/upload/2023/5\0e84a43a-4b20-4e33-a0b7-825f7c838f7c.png)
- 1355357-49-1
(2R,3R,4R,5R)‐2‐{4‐aminopyrrolo[2,1‐f][1,2,4]triazin‐7‐yl}‐3,4‐bis(benzyloxy)‐5‐[(benzyloxy)methyl]tetrahydrofuran‐2‐carbonitrile
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![(2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile](/upload/2023/5\0ccf2689-60a2-4ee0-9946-487207b7ca3c.png)
- 1191237-69-0
(2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile
| Conditions | Yield |
|---|---|
|
With boron trichloride; In dichloromethane; at 5 ℃;
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95% |
|
With 5%-palladium/activated carbon; hydrogen; In ethanol; at 45 - 50 ℃; under 750.075 - 900.09 Torr; Solvent; Reagent/catalyst;
|
91.1% |
|
(2R,3R,4R,5R)‐2‐{4‐aminopyrrolo[2,1‐f][1,2,4]triazin‐7‐yl}‐3,4‐bis(benzyloxy)‐5‐[(benzyloxy)methyl]tetrahydrofuran‐2‐carbonitrile; With boron trichloride; In dichloromethane; at -78 - -40 ℃; for 2h; Inert atmosphere;
With methanol; triethylamine; In dichloromethane;
|
85% |
|
With methanol; boron trichloride; triethylamine; In dichloromethane; for 0.0433333h; Temperature; Flow reactor;
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82% |
|
With boron trichloride; In dichloromethane; at -78 ℃; Inert atmosphere;
|
70% |
|
With boron trichloride; In dichloromethane; at -20 - -15 ℃; for 1h;
|
|
|
Multi-step reaction with 2 steps
1.1: boron trichloride; Trimethyl borate / dichloromethane / 2 h / 0 - 35 °C
1.2: 12 h / 20 - 25 °C
2.1: potassium carbonate / water / 1 h / 20 °C
With Trimethyl borate; boron trichloride; potassium carbonate; In dichloromethane; water;
|
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![(3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy) methyl)tetrahydrofuran-2-carbonitrile](/upload/2023/5\548ed445-3e50-4ebe-b74d-be6e9cf21e18.png)
- 1191237-68-9
(3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy) methyl)tetrahydrofuran-2-carbonitrile
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- 1191237-69-0
(2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile
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![(2S,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile](/upload/2023/5\f3c1392b-6858-4069-aead-d539323d5c15.png)
- 1355049-95-4
(2S,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
| Conditions | Yield |
|---|---|
|
(3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy) methyl)tetrahydrofuran-2-carbonitrile; With boron trichloride; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;
With methanol; In dichloromethane;
|
37% 37% |
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With boron trichloride; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;
|
37% 37% |
|
With boron trichloride; In dichloromethane; at -78 - 0 ℃; for 3h;
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6% 22% |
|
In dichloromethane; at -78 ℃; for 1h;
|
|
|
With boron trichloride; In dichloromethane; at -78 - -20 ℃; for 1h; Inert atmosphere;
|
2.What is the CAS number for GS-441524 ?
The CAS number of GS-441524 is 1191237-69-0.
More information of GS-441524 1191237-69-0 are:
|
CAS Number |
1191237-69-0 |
|
Density |
1.84±0.1 g/cm3(Predicted) |
|
Melting Point |
> 233° C (dec.) |
3.What are another words for GS-441524 ?
Synonyms for GS-441524 1191237-69-0:(2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile
4.What is the molecular formula of GS-441524?
The chemical formula of GS-441524 is C12H13N5O4 and the formula weight of GS-441524 is 291.266.
5.What is GS-441524 (1191237-69-0) used for?
GS-441524 was highly efficacious in reducing the viral titers in CoV-infected organs without notable toxicity. GS-441524 has potential for oral treatment of Covid-19. GS-441524 shows comparable efficacy in Cell-Based models of primary human lung and cat cells infected with coronavirus.
Relevant articles related to (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile:
|
Article |
Source |
| Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses | European Journal of Medicinal Chemistry Volume 249, 5 March 2023, 115113 |
| Population pharmacokinetics and exposure–clinical outcome relationship of remdesivir major metabolite GS-441524 in patients with moderate and severe COVID-19 | CPT: Pharmacometrics & Systems Pharmacology, Volume12, Issue4 April 2023 Pages 513-521 |
6.Hot sale! High purity GS-441524 1191237-69-0 powder
Shandong Hanjiang Chemical Co., Ltd. is a quality supplier of GS-441524. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on high purity GS-441524 1191237-69-0.
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